![]() The findings are relevant to understanding normal development and also may be useful in cancer research, said University of Illinois Urbana-Champaign cell and developmental biology professor and department head Supriya Prasanth, who led the research. Once they differentiate, they usually stop actively proliferating. Only when BEND3 is downregulated can cells adopt their final form and function. They discovered that a molecule known as BEND3 shuts down expression of hundreds of genes associated with differentiation, maintaining the cell's stem cell-like status. ![]() ![]() In a study published in the Proceedings of the National Academy of Sciences, researchers report that they have identified a key regulator of this process. Scientists have long sought to understand the signals that prompt stem cells to switch off pluripotency and adopt their final functional state. Feb 22 2022Įmbryonic stem cells and other pluripotent cells divide rapidly and have the capacity to become nearly any cell type in the body.
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